Recombinant Human Natural Killer Cell Receptor 2B4/SLAMF4/CD244 (C-6His)
Produktgrößen
10 µg
£493,00
32-8946-10UG
50 µg
£656,00
32-8946-50UG
Über dieses Produkt
- SKU:
- 32-8946
- Weitere Details:
- Source: Human Cells. MW :23.1kD. Recombinant Human Natural Killer Cell Receptor 2B4 is produced by our Mammalian expression system and the target gene encoding Cys22-Arg221 is expressed with a 6His tag at the C-terminus. Natural killer cell receptor 2B4 is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family.2B4 interacts with CD48; while other SLAM family proteins interact homophilically. Three additional splice variants of human 2B4 have deletions of the short region between the Ig-like domains; the second Ig-like domain; or a portion of the cytoplasmic tail.2B4 is expressed on all NK cells; gamma delta T cells; monocytes; some CD4+ and CD8+ T cells; and some dendritic cells. CD48 mediates 2B4+ cell interactions with nearly all hematopoietic cell types; including cells of the same type. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can either directly trigger inhibitory signaling or disrupt an inhibitory interaction; leading to cellular activation. The inhibitory effect is associated with the long form of 2B4; while the activation is associated with the short form. 2B4 can also induce signaling through CD48.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php