Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)
Produktgrößen
10 µg
£499,00
32-8913-10UG
50 µg
£656,00
32-8913-50UG
Über dieses Produkt
- SKU:
- 32-8913
- Weitere Details:
- Source: Human cells. MW :23.5kD. Recombinant Mouse Natural killer cell receptor 2B4 is produced by our Mammalian expression system and the target gene encoding Gln20-Asn221 is expressed with a 6His tag at the C-terminus. Natural killer cell receptor 2B4 (2B4/CD244) is is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4 interacts with CD48; while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence; a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain; a 21 aa transmembrane segment; and a 150 aa cytoplasmic domain with four ITSMs. Within the ECD; mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4; respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction; leading to cellular activation. 2B4 can also induce signaling through CD48.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php