Recombinant Cynomolgus Fibroblast Growth Factor 21/FGF-21 (C-6His)
Produktgrößen
10 µg
£508,00
32-8909-10UG
50 µg
£722,00
32-8909-50UG
Über dieses Produkt
- SKU:
- 32-8909
- Weitere Details:
- Source: Human Cells. MW :20.2kD. Recombinant Cynomolgus Fibroblast Growth Factor 21 (Accession No.-XM_005589811.2) is produced by our Mammalian expression system and the target gene encoding His29-Ser209 is expressed with a 6His tag at the C-terminus. Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues; by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes; protects animal from diet-induced obesity when overexpression in transgenic mice; and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation; or following the ingestionof a highly-fat/low-carbohydrate diet. Upon FGF21 secretion; white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes; they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies; release; and transported to peripheral tissue for TCA processing and energy generation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php