Recombinant Mouse RANK/TNFRSF11A (C-6His)
Produktgrößen
10 µg
£499,00
32-8908-10UG
50 µg
£656,00
32-8908-50UG
Über dieses Produkt
- SKU:
- 32-8908
- Weitere Details:
- Source: Human Cells. MW :21.3kD. Recombinant Mouse Receptor Activator of NF-kappa B is produced by our Mammalian expression system and the target gene encoding Val31-Ser214 is expressed with a 6His tag at the C-terminus. Receptor activator of NF-?B(RANK;TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide; 184 aa extracellular region ; a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone; thymus; small intestine; lung; brain and kidney; but weakly expressed in spleen and bone marrow. After binding its ligand RANKL; RANK can activate signaling pathways such as NF-?B; JNK; ERK; p38; and Akt/PKB; through TRAF protein phosphorylation. RANK/TNFRSF11A signaling is largely considered to be growth promoting and apoptosis reducing such as the effects observed in osteoclasts. RANK/TNFRSF11A was also found to be involved in the regulation of interactions between T-cells and dendritic cells.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php