Recombinant Mouse SLAM/CD150 (C-6His)
Produktgrößen
10 µg
£499,00
32-8907-10UG
50 µg
£656,00
32-8907-50UG
Über dieses Produkt
- SKU:
- 32-8907
- Weitere Details:
- Source: Human Cells. MW :25.2kD. Recombinant Mouse Signaling Lymphocytic Activation Molecule is produced by our Mammalian expression system and the target gene encoding Thr25-Pro242 is expressed with a 6His tag at the C-terminus. Signaling lymphocyte activation molecule (SLAM); is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells; but also on the surface of activated B cells; dendritic cells; and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains;transmembrane segment; and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR-dependent responses. SLAM; together with CD46; is one of the two receptors for measles virus. SLAM is a cell surface receptor that; like the B cell receptor; CD40; and CD95; can transmit positive or negative signals. SLAM can associate with the SH2-containing inositol phosphatase (SHIP); the SH2-containing protein tyrosine phosphatase (SHP-2); and the adaptor protein SH2 domain protein 1A. It’s upregulated on activated B cells and CD4+ and CD8+ T cells; but downregulated on Th2 polarized cells. Also; it can Inhibits antigen receptor-mediated production of IFN-gamma; but not IL-2; in CD4-/CD8- T-cells
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php