Recombinant Human Artemin
Produktgrößen
10 µg
£543,00
32-8884-10UG
50 µg
£706,00
32-8884-50UG
Über dieses Produkt
- SKU:
- 32-8884
- Weitere Details:
- Source: E. coli. MW :12.1kD. Recombinant Human Artemin is produced by our E.coli expression system and the target gene encoding Ala108-Gly220 is expressed. Human Artemin is a GDNF family ligand that is distantly related to the TGF- beta superfamily of molecules. It is synthesized as a preproprotein; and contains a variable length pre-; or signal sequence; plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Alternate splicing and start sites create signal sequences of 22; 30 and 39 aa; respectively. Following synthesis and proteolytic processing; mature ARTN is secreted as a presumably glycosylated; 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF- beta signature cysteine-knot motif. In the mature region; human ARTN is 89% and 88% aa identical to rat and mouse ARTN; respectively. Human ARTN is active on rodent cells. The receptor for ARTN has been identified as the ligand binding subunit GFRa-3 plus the signal transducing subunit; RET. The GFRa-1/RET receptor complex has also been suggested to be a ligand binding unit or ARTN. ARTN is known to be a chemoattractant for sympathetic neuron axons innervating the developing cardiovascular system. It also promotes sensory neuron survival and likely plays a role in the development of the peripheral nervous system. Finally; it has been reported to reverse neuropathic pain due to nerve injury; and to help resolve morphological changes associated with nerve damage.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php