Recombinant Mouse C-C motif chemokine 2/CCL2
Produktgrößen
10 µg
£604,00
32-8859-10UG
50 µg
£897,00
32-8859-50UG
Über dieses Produkt
- SKU:
- 32-8859
- Weitere Details:
- Source: E.coli. MW :8.5kD. Recombinant Mouse C-C motif Chemokine 2 is produced by our E.coli expression system and the target gene encoding Gln24-Arg96 is expressed. C-C motif chemokine 2 (CCL2) is a member of the C-C or beta chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence; and 58%; 56%; 55%; 53% and 53% aa identity with human; equine; porcine; bovine and canine CCL2; respectively. Fibroblasts; glioma cells; smooth muscle cells; endothelial cells; lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation; but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity; CCL2 induces enzyme and cytokine release by monocytes; NK cells and lymphocytes; and histamine release by basophils that express its receptor; CCR2. Additionally; it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis; multiple sclerosis and allergic asthma.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php