Recombinant Human Tryptase alpha/beta-1/TPSAB1 (C-6His)
Produktgrößen
10 µg
£564,00
32-8840-10UG
50 µg
£857,00
32-8840-50UG
Über dieses Produkt
- SKU:
- 32-8840
- Weitere Details:
- Source: Human Cells. MW :28.8kD. Recombinant Human Tryptase alpha/beta-1 is produced by our Mammalian expression system and the target gene encoding Ile31-Pro275 is expressed with a 6His tag at the C-terminus. Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G; tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1); also known as mast cell protease 7 (MCPT7); it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung; stomach; spleen; heart and skin; in these tissues; isoform 1 is predominant. Isoform 2 is expressed in aorta; spleen; and breast tumor; with highest levels in the endothelial cells of some blood vessels surrounding the aorta; as well as those surrounding the tumor and low levels; if any; in mast cells. Isoform 2 cleaves large substrates; such as fibronectin; more efficiently than isoform 1; but seems less efficient toward small substrates. It may play a role in innate immunity.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:TPSAB1.jpg