Recombinant Mouse Signal-Regulatory Protein a-1/SIRPA/CD172a (C-MIgG2a)
Produktgrößen
10 µg
£549,00
32-8829-10UG
50 µg
£706,00
32-8829-50UG
Über dieses Produkt
- SKU:
- 32-8829
- Weitere Details:
- Source: Human cells. MW :65.1kD. Recombinant Mouse Signal-Regulatory Protein alpha 1 is produced by our Mammalian expression system and the target gene encoding Lys32-Asn372 is expressed with a MIgG2a tag at the C-terminus. SIRPa is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%; 75%; 62%; 61%; and 59% aa sequence identity with human; rat; equine; bovine; and porcine SIRP alpha; respectively.SIRPa can express in various tissues; mainly on brain and myeloid cells; including macrophages; neutrophils; dendritic and Langerhans cells. It also can detect in neurons; smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPa acts as docking protein and induces translocation of PTPN6; PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPa shows adhesion of cerebellar neurons; neurite outgrowth and glial cell attachment. SIRPa engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis; mast cell activation and dendritic cell activation.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php