Recombinant Human Importin Subunit Beta-1/KPNB1(N-6His)
Produktgrößen
10 µg
£604,00
32-8821-10UG
50 µg
£897,00
32-8821-50UG
Über dieses Produkt
- SKU:
- 32-8821
- Weitere Details:
- Source: E.coli. MW :98.6kD. Recombinant Human Importin Subunit Beta-1 is produced by our E.coli expression system and the target gene encoding Met1-Ala876 is expressed with a 6His tag at the N-terminus. Importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport; a signal- and energy-dependent process; takes place through nuclear pore complexes embedded in the nuclear envelope. Its functions in nuclear protein import; either in association with an adapter protein; like an importin-alpha subunit; which binds to nuclear localization signals (NLS) in cargo substrates; or by acting as autonomous nuclear transport receptor. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor; a heterodimer of importin alpha and beta subunits. Each of these subunits is part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. It mediates autonomously the nuclear import of ribosomal proteins RPL23A; RPS7 and RPL5.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php