Recombinant Mouse Triggering Receptor Expressed on Myeloid Cells 2b/TREM-2b (C-6His)
Produktgrößen
10 µg
£549,00
32-8758-10UG
50 µg
£706,00
32-8758-50UG
Über dieses Produkt
- SKU:
- 32-8758
- Weitere Details:
- Source: Human Cells. MW :17.3kD. Recombinant Mouse TREM-2b is produced by our Mammalian expression system and the target gene encoding Leu19-Pro168 is expressed with a 6His tag at the C-terminus. Triggering receptor expressed on myeloid cells-2 (TREM-2) is a cell surface receptor primarily expressed on macrophages; osteoclasts; microglia and dendritic cells. TREM-2 is one member of the TREM family; inhibiting the releasing of inflammatory mediators; so it is an important in vivo anti-inflammatory receptor. TREM-2 consists of an 18 aa signal sequence; a 153 aa extracellular domain (ECD) with one V-type Ig-like domain; a 21 aa transmembrane (TM) domain; and a 35 aa cytoplasmic tail. A soluble form of TREM-2 (TREM-2b) created by alternate splicing diverges at aa 161. TREM-2 transduces intracellular signals through the adaptor DAP12. After binding of TREM-2 with ligand; the TREM-2/DAP12 (dead-cell-activated-receptor-associated protein)-mediated signal transduction pathway causes a series of intracellular protein tyrosine phosphorylation reactions and enzymatic reactions; which then activate the myeloid cells and participate T cell responses.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Cells
- Datenblatt des Herstellers:download_pdf.php