Recombinant Human IL-15 Receptor a & IL-15 Fusion Protein/IL15RA&IL15 (C-Fc)
Produktgrößen
10 µg
£408,00
32-8662-10UG
50 µg
£610,00
32-8662-50UG
Über dieses Produkt
- SKU:
- 32-8662
- Weitere Details:
- Source: Human Cells. MW :46.9kD. Recombinant Human IL-15 Ra & IL-15 fusion protein is produced by our Mammalian expression system and the target gene encoding Ile31-Asp96&Asn49-Ser162 is expressed with a Fc tag at the C-terminus. Interleukin-15 receptor subunit alpha; also known as Il15ra; is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain; or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified; resulting from alternative splicing events involving different exons.Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor; but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors; allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties; IL-2 and IL-15 are; in fact; quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues; including monocytes; macrophages and DCs.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:32-8662 .jpg