Recombinant Mouse Chordin-Like Protein 2/CHL2/CHRDL2 (C-6His)
Produktgrößen
10 µg
£499,00
32-8638-10UG
50 µg
£656,00
32-8638-50UG
Über dieses Produkt
- SKU:
- 32-8638
- Weitere Details:
- Source: Human Cells. MW :46.3kD. Recombinant Mouse Chordin-like protein 2 is produced by our Mammalian expression system and the target gene encoding Gln24-Leu426 is expressed with a 6His tag at the C-terminus. Mouse Chordin-Like 2; also known as CHL2; is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide. The mature chain of CHL2 protein contains two potential N-linked glycosylation sites; one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs). CHL2 gene is weakly expressed in the liver and kidney; partly expressed in the connective tissues of reproductive organs such as ligaments of the ovary and oviduct in females; and of testis; epididymis and certain male accessory sex glands in males. Recombinant mCHL2 protein interacted directly with five BMPs and one GDF thereby inhibiting; in vitro; several BMP/GDF-dependent processes including; osteogenic differentiation of C2C12 mesenchymal progenitor cells by several BMPs; ATDC5 embryonal carcinoma cells by GDF5 and BMP4-dependent lymphohematopoietic (CD34+CD31hi and CD34+CD31lo) progenitor cell development from ES cells. CHL2 may inhibits BMPs activity by blocking their interaction with their receptors; and has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells; by preventing or reducing the rate of matrix accumulation. Also; it may play a role during myoblast and osteoblast differentiation; and maturation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php