Recombinant Mouse TIGIT/VSIG9/VSTM3 (C-6His)
Produktgrößen
10 µg
£499,00
32-8623-10UG
50 µg
£656,00
32-8623-50UG
Über dieses Produkt
- SKU:
- 32-8623
- Weitere Details:
- Source: Human Cells. MW :13.3kD. Recombinant Mouse TIGIT is produced by our Mammalian expression system and the target gene encoding Gly26-Phe135 is expressed with a 6His tag at the C-terminus. T cell immunoreceptor with Ig and ITIM domains (TIGIT); also called WUCAM; VSIG9 and Vstm3; is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain; a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM); and is expressed on regulatory; memory; activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC); macrophages and endothelium with high affinity; and CD112(PVRL2) with lower affinity; but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10; but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges; while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php