Recombinant Mouse Interferon gamma Receptor 1/IFN-gamma R1/CD119 (C-6His)
Produktgrößen
10 µg
£427,00
32-8610-10UG
50 µg
£474,00
32-8610-50UG
Über dieses Produkt
- SKU:
- 32-8610
- Weitere Details:
- Source: Human Cells. MW :26.9kD. Recombinant Mouse Interferon gamma Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala26-Asp253 is expressed with a 6His tag at the C-terminus. The tetrameric receptor complex for IFN gamma consists of two subunits; IFNGR1 (IFN gamma R alpha ) and IFNGR2 (IFN gamma R beta ); through which the dimeric IFN- gamma exerts its biological functions; including antiviral; antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1; widely expressed in most host cells; is essential for IFN gamma binding; receptor trafficking; and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site; a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php