Recombinant Mouse Interleukin-36b/IL-36b/IL1F8
Produktgrößen
10 µg
£508,00
32-8595-10UG
50 µg
£625,00
32-8595-50UG
Über dieses Produkt
- SKU:
- 32-8595
- Weitere Details:
- Source: E.coli. MW :17.6kD. Recombinant Mouse Interleukin-36 beta is produced by our E.coli expression system and the target gene encoding Ser31-Lys183 is expressed. Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesized in several cells including resting and activated monocytes; and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts; articular chondrocytes and mature adipocytes; inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases ; inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs); including IL-12; Il-1 beta; IL-6; TNF-alpha and IL-23; and activating p38 MAPK phosphorylation in BMDCs.Moreover; interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes; dendritic cells; and indirectly on T cells to drive tissue infiltration; cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80; CD86 and MHC class II and inducing the production of IFN-gamma; IL-4 and IL-17 by T helper 1 (Th1) cells; cultured CD4+ T cells and splenocytes.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php