Recombinant Mouse a-Synuclein/SNCA (N-6His)
Produktgrößen
10 µg
£554,00
32-8593-10UG
50 µg
£847,00
32-8593-50UG
Über dieses Produkt
- SKU:
- 32-8593
- Weitere Details:
- Source: E.coli. MW :15.9kD. Recombinant Mouse alpha-Synuclein is produced by our E.coli expression system and the target gene encoding Met1-Ala140 is expressed with a 6His tag at the N-terminus. Alpha-synuclein (Snca) belongs to a family of proteins including a-; b-; and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases; including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure; especially for proteins important in the pathogenesis of neurodegenerative diseases. Alpha-synuclein is a dynamic molecule whose secondary structure depends on the environment. For example; it has an unfolded random coil structure in aqueous solution; forms a-helical structure upon binding to acidic phospholipid vesicles; and forms insoluble fibrils with a high b-sheet content that resemble the filaments found in Lewy bodies. Also; alpha-synuclein was known to associate with 14-3-3 proteins including protein kinase C; BAD; and extracellular regulated kinase; and overexpression of alpha-synuclein could contribute to cell death in neurodegenerative diseases.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php