Recombinant Mouse PD-L2/B7-DC/CD273 (C-Fc)
Produktgrößen
10 µg
£453,00
32-8570-10UG
50 µg
£544,00
32-8570-50UG
Über dieses Produkt
- SKU:
- 32-8570
- Weitere Details:
- Source: Human Cells. MW :49.7kD. Recombinant Mouse Programmed Cell Death 1 Ligand 2 is produced by our Mammalian expression system and the target gene encoding Leu20-Arg219 is expressed with a Fc tag at the C-terminus. Programmed cell death 1 ligand 2 (PD-L2); also known as butyrophilin B7-DC or PDCD1 ligand 2; belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1); and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide; a 201 aa extracellular region ; a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart; placenta; pancreas; lung and liver while expressed weakly in spleen; lymph nodes and thymus. Besides; the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment; and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells; at both the induction and effector phase of antitumor immunity. Moreover; PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php