Recombinant Mouse PDCD1/PD-1/CD279 (C-Fc)
Produktgrößen
10 µg
£453,00
32-8568-10UG
50 µg
£544,00
32-8568-50UG
Über dieses Produkt
- SKU:
- 32-8568
- Weitere Details:
- Source: Human Cells. MW :43.3kD. Recombinant Mouse Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a Fc tag at the C-terminus. Programmed Death-1 (PD-1); firstly cloned from mouse T cell hybridoma 2B4.11; is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28; CTLA-4 and ICOS.The mouse Programmed Death-1 protein; encoded by PD-1 gene; comprises four parts including a putative 20 aa signal peptide; a 149 aa extracellular region; a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs; an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently; programmed death-1 (PD-1) with its ligands; programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2); was found to regulate T-cell activation and tolerance; upon ligand binding; inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases; which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus; PD-1 may be a useful target for the immunologic therapy of carcinoma;infection;autoimmune diseases as well as organ transplantation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php