Recombinant Human VEGF Receptor 2/VEGF R2/FLK-1/KDR (C-Fc)
Produktgrößen
10 µg
£493,00
32-8563-10UG
50 µg
£656,00
32-8563-50UG
Über dieses Produkt
- SKU:
- 32-8563
- Weitere Details:
- Source: Human Cells. MW :110.4kD. Recombinant Human Vascular Endothelial Growth Factor Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ala20-Glu764 is expressed with a Fc tag at the C-terminus. Human Vascular endothelial growth factor receptor 2(KDR; VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis; vascular development; vascular permeability; and embryonic hematopoiesis. It also plays an essential role in promoting proliferation; survival; migration and differentiation of endothelial cells; reorganization of the actin cytoskeleton. VEGFR2 is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors; whose expression is restricted to endothelial cells in vivo.The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition; VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation; and seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth; while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php