Recombinant Mouse Semaphorin 4D/SEMA4D (C-Fc)
Produktgrößen
10 µg
£493,00
32-8485-10UG
50 µg
£656,00
32-8485-50UG
Über dieses Produkt
- SKU:
- 32-8485
- Weitere Details:
- Source: Human Cells. MW :103.4kD. Recombinant Mouse Semaphorin 4D is produced by our Mammalian expression system and the target gene encoding Phe24-Met711 is expressed with a Fc tag at the C-terminus. SEMA4D is a member of the semaphorin family;contains one Ig-like C2-type domain; one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues; especially in the thymus; as well as in the nervous tissues. However; SEMA4D is expressed at lower levels in testes; brain; kidney; small intestine; prostate; heart; placenta; lung and pancreas; but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. SEMA4D is involved in a number of fundamental biological processes such as promoting reorganization of the actin cytoskeleton; the migration of cerebellar granule cells and of endothelial cells and signaling via SRC and PTK2B/PYK2; which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Not only these; it plays a role in axonal growth cone guidance in the developing central nervous system. Semaphorin-4D / SEMA4D may play a functional role in the immune system; as well as in the nervous system. It could induce B-cells to aggregate and improves their viability (in vitro). SEMA4D is involved in regulating dendrite and axon branching and morphogenesis and promoting interaction with PLXNB1 mediates activation of RHOA.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php