Recombinant Human Signal Transducer and Activator of Transcription 5B/STAT5B (C-6His)
Produktgrößen
10 µg
£605,00
32-8234-10UG
50 µg
£898,00
32-8234-50UG
Über dieses Produkt
- SKU:
- 32-8234
- Weitere Details:
- Source: E. coli. MW :38.4kD. Recombinant Human STAT5B is produced by our E.coli expression system and the target gene encoding Met1-Thr321 is expressed with a 6His tag at the C-terminus. Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth; survival; differentiation; motility; and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands; such as IL2; IL4; CSF1; and different growth hormones. It has been shown to be involved in diverse biological processes; such as TCR signaling; apoptosis; adult mammary gland development; and sexual dimorphism of liver gene expression. Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22; IL6). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and; upon phosphorylation; translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation; differentiation and survival.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php