Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15
Produktgrößen
10 µg
£508,00
32-8181-10UG
50 µg
£722,00
32-8181-50UG
Über dieses Produkt
- SKU:
- 32-8181
- Weitere Details:
- Source: E. coli. MW :15.3kD. Recombinant Human Astrocytic Phosphoprotein PEA-15 is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed. Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system; principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition; PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present; PEA15 expression is also a significant prognostic marker in ovarian cancer.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php