Recombinant Human Growth Factor Receptor-Bound Protein 2/GRB2/ASH (C-6His)
Produktgrößen
10 µg
£554,00
32-8061-10UG
50 µg
£847,00
32-8061-50UG
Über dieses Produkt
- SKU:
- 32-8061
- Weitere Details:
- Source: E.coli. MW :26.3kD. Recombinant Human GRB2 is produced by our E.coli expression system and the target gene encoding Met1-Val217 is expressed with a 6His tag at the C-terminus. As an adaptor protein; Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain; stimulating GTP binding to Ras; which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1; IRS1; IRS4; SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php