Recombinant Human Activin Receptor 1B/Activin RIB/ALK-4/ACVR1B (C-6His)
Produktgrößen
10 µg
£453,00
32-7785-10UG
50 µg
£508,00
32-7785-50UG
Über dieses Produkt
- SKU:
- 32-7785
- Weitere Details:
- Source: Human Cells. MW :12.46kD. Recombinant Human Activin Receptor IB is produced by our Mammalian expression system and the target gene encoding Ser24-Glu126 is expressed with a 6His tag at the C-terminus. Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues; most strongly in kidney; pancreas; brain; lung; and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B; ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs; SMAD2 and SMAD3. ACVR1B also transducers signals of nodal; GDF-1; and Vg1. Mutations in ACVR1B are associated with pituitary tumors.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php