Recombinant Human Sialate O-Acetylesterase/SIAE (C-6His)
Produktgrößen
10 µg
£604,00
32-7750-10UG
50 µg
£897,00
32-7750-50UG
Über dieses Produkt
- SKU:
- 32-7750
- Weitere Details:
- Source: Human Cells. MW :57kD. Recombinant Human Sialate O-Acetylesterase is produced by our Mammalian expression system and the target gene encoding Ile24-Lys523 is expressed with a 6His tag at the C-terminus. Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases; specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis; prostate; and colon. SIAE catalyzes N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid; N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22); and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php