Recombinant Human Coagulation Factor XIII A Chain (C-6His)
Produktgrößen
10 µg
£564,00
32-7685-10UG
50 µg
£787,00
32-7685-50UG
Über dieses Produkt
- SKU:
- 32-7685
- Weitere Details:
- Source: Human Cells. MW :80.3kD. Recombinant Human Coagulation Factor XIII A Chain is produced by our Mammalian expression system and the target gene encoding Gly39-Met732 is expressed with a 6His tag at the C-terminus. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function; and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits; which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion; the plasma factor XIII dissociates its B subunits and yields the same active enzyme; factor XIIIa; as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules; thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency; characterized by the lack of both the A and B subunits; and type II deficiency; characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency; defective wound healing; and habitual abortion.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php