Recombinant Human Triggering Receptor Expressed On Myeloid 2/TREM-2 (C-6His)
Produktgrößen
10 µg
£499,00
32-7660-10UG
50 µg
£669,00
32-7660-50UG
Über dieses Produkt
- SKU:
- 32-7660
- Weitere Details:
- Source: Human Cells. MW :18.3kD. Recombinant Human Triggering Receptor Expressed On Myeloid Cells 2 is produced by our Mammalian expression system and the target gene encoding His19-Ser174 is expressed with a 6His tag at the C-terminus. Triggering Receptor Expressed on Myeloid cells 2 (TREM2)is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain; a 21 aa transmembrane (TM) domain; and a 35 aa cytoplasmic tail. Soluble forms of the TREM2 ECD are generated by alternative splicing or proteolytic cleavage; and the cytoplasmic domain can be liberated by gamma-Secretase mediated intramembrane cleavage. A positively charged lysine within the transmembrane segment allows association with the signal adapter protein; DAP12 and inhibition of macrophage activation. TREM2 is expressed on macrophages; immature myeloid dendritic cells; osteoclasts; microglia; and adipocytes.It promotes the differentiation and function of osteoclasts; the production of inflammatory cytokines by adipocytes; insulin resistance; and the phagocytic clearance of bacteria.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php