Recombinant Mouse Interleukin-36 a/Il36a/IL-1F6
Produktgrößen
10 µg
£514,00
32-7601-10UG
50 µg
£737,00
32-7601-50UG
Über dieses Produkt
- SKU:
- 32-7601
- Weitere Details:
- Source: E.coli. MW :17.27kD. Recombinant Mouse Interleukin-36 alpha is produced by our E.coli expression system and the target gene encoding Arg8-His160 is expressed. Mouse Interleukin-36 alpha(Il-36a)is a member of the IL-1 family.IL¬1a;IL¬1 beta and IL-18 are potent inflammatory cytokines whose activities are dependent on heterodimeric receptors of the IL-1R superfamily; and which are regulated by soluble antagonists. Il36a is expressed in many cells; including monocytes; B cells; and T cells; immune system and fetal brains. Il36a is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. It is a part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. It seems to be involved in skin inflammatory response by acting on keratinocytes; dendritic cells and indirectly on T cells to drive tissue infiltration; cell maturation and cell proliferation. It Induces the production of proinflammatory cytokines; including IL-12; Il-1 beta; IL-6; TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Moreover; it is involved in dendritic cell maturation by stimulating the surface expression of CD80; CD86 and MHC class II and can induce the production of IFN-gamma; IL-4 and IL-17 by cultured CD4+ T cells and splenocytes. Il36a may play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung; and the expression of TNF-alpha; IL-36c; IL-1A; IL-1B; CXCL1 and CXCL2 in isolated splenic CD11c+ alveolar macrophages. It may be involved in T cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c+ cells and CD4+ T cell proliferation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php