Recombinant Human Vascular Non-Inflammatory Molecule 1/Vanin-1/VNN1 (C-6His)
Produktgrößen
10 µg
£514,00
32-7498-10UG
50 µg
£737,00
32-7498-50UG
Über dieses Produkt
- SKU:
- 32-7498
- Weitere Details:
- Source: Human Cells. MW :53.27kD. Recombinant Human Vascular Non-Inflammatory Molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln22-Ser490 is expressed with a 6His tag at the C-terminus. Vanin-1 is a cell membrane protein which contains one CN hydrolase domain and belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 is also a member of the Vanin family of proteins; which share extensive sequence similarity with each other; and also with biotinidase. The family includes secreted and membrane-associated proteins; a few of which have been reported to participate in hematopoietic cell trafficking. Vanin-1 is widely expressed with higher expression in spleen; kidney and blood and overexpressed in lesional psoriatic skin. No biotinidase activity has been demonstrated for any of the vanin proteins; however; they possess pantetheinase activity; which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes; and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological; noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sub-lethal irradiation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php