Recombinant Human VEGF-C (C-6His)
Produktgrößen
10 µg
£526,00
32-7497-10UG
50 µg
£774,00
32-7497-50UG
Über dieses Produkt
- SKU:
- 32-7497
- Weitere Details:
- Source: Human Cells. MW :23.27kD. Recombinant Human Vascular Endothelial Growth Factor C is produced by our Mammalian expression system and the target gene encoding Phe32-Arg227 is expressed with a 6His tag at the C-terminus. Vascular Endothelial Growth Factor (VEGF)-C is a member of the VEGF family; a group of polypeptide growth factors which play key roles in the physiology and pathology of many aspects of the cardiovascular system; including vasculogenesis; hematopoiesis; angiogenesis and vascular permeability. While VEGFC is homologous to other members of the VEGF/PDGF family; it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis; VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF signalling in endothelial cells occurs through three tyrosine kinase receptors (VEGFRs) expressed by endothelial cells and hematopoietic precursors; and VEGF-C is a ligand for two receptors; VEGFR-3 (Flt4); and VEGFR-2. It is indicated that VEGFC undergoes a complex proteolytic maturation generating a variety of processed secreted forms with increased activity toward VEGFR-3; but only the fully processed form could activate VEGFR-2. VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis; and also in the maintenance of differentiated lymphatic endothelium in adults. Knockout of the VEGF-C gene is embryonic lethal late in development; and although cells differentiate into the lymphatic lineage; they fail to sprout and form lymphatic vessels. Inactivation of a single VEGF-C allele results in the development of cutaneous lymphatic hypoplasia and lymphedema.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php