Recombinant Human Oxidized Low-Density Lipoprotein Receptor 1/OLR1 (C-6His)
Produktgrößen
10 µg
£488,00
32-7475-10UG
50 µg
£636,00
32-7475-50UG
Über dieses Produkt
- SKU:
- 32-7475
- Weitere Details:
- Source: Human Cells. MW :25.39kD. Recombinant Human LOX-1 is produced by our Mammalian expression system and the target gene encoding Ser61-Gln273 is expressed with a 6His tag at the C-terminus. Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted; single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta; lung; liver; brain; aortic intima; bone marrow; spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF; IFNG and IL6 by pathological conditions; such as hyperlipidemia; hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition; internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release; monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL; which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells; thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process; by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php