Recombinant Human Interferon a/ beta Receptor 2/IFNAR2 (C-6His)
Produktgrößen
10 µg
£488,00
32-7430-10UG
50 µg
£636,00
32-7430-50UG
Über dieses Produkt
- SKU:
- 32-7430
- Weitere Details:
- Source: Human Cells. MW :25.79kD. Recombinant Human Interferon alpha/beta Receptor 2 is produced by our Mammalian expression system and the target gene encoding Ile27-Lys243 is expressed with a 6His tag at the C-terminus. Interferon a/ beta Receptor 2 (IFN-a/ beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-a/ beta R1 to form the signaling receptor complex for the family of a and beta IFN subtypes. By alternative splicing; IFN-a/ beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-a/ beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-a/ beta R1; resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes; monocytes; and granulocytes; although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets; IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase; JAK1. Isoform 1 also interacts with the transcriptional factors; STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php