Recombinant Human GDNF Receptor a-2/GFRA2 (C-6His)
Produktgrößen
10 µg
£445,00
32-7426-10UG
50 µg
£530,00
32-7426-50UG
Über dieses Produkt
- SKU:
- 32-7426
- Weitere Details:
- Source: Human Cells. MW :47.79kD. Recombinant Human GDNF Family Receptor alpha-2 is produced by our Mammalian expression system and the target gene encoding Ser22-Ser441 is expressed with a 6His tag at the C-terminus. Members of the glial cell line-derived neurotrophic factor (GDNF) family; including GDNF and Neurturin; play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated; disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors; GFRa-1; GFRa-2; and GFRa-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRa-1 and GFRa-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFRa-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php