Recombinant Human GDNF Family Receptor a-1/GFRA1 (C-6His)
Produktgrößen
10 µg
£445,00
32-7425-10UG
50 µg
£530,00
32-7425-50UG
Über dieses Produkt
- SKU:
- 32-7425
- Weitere Details:
- Source: Human Cells. MW :46.28kD. Recombinant Human GDNF Family Receptor alpha-1 is produced by our Mammalian expression system and the target gene encoding Asp25-Lys429 is expressed with a 6His tag at the C-terminus. Glial Cell Line-Derived Neurotrophic Factor Family Receptor a-1 (GDNFRa1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor a subtype which consists of at least four members. GFRa1and GFRa2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFRas released enzymatically from the cell surface by phosphatidylinositol phospholipase C; as well as recombinantly produced soluble GFRa1; can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFRa1 shares 93% amino acid identity with mouse GFRa1.The expression of the various GFRas are differentially regulated in the central and peripheral nervous system; suggesting complementary roles for the GFRas in mediating the activities of the GDNF family of neurotrophic factors.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php