Recombinant Human Poliovirus Receptor-Related Protein 2/PVRL2/CD112 (C-6His)
Produktgrößen
10 µg
£488,00
32-7394-10UG
50 µg
£636,00
32-7394-50UG
Über dieses Produkt
- SKU:
- 32-7394
- Weitere Details:
- Source: Human Cells. MW :36.58kD. Recombinant Human Nectin-2 is produced by our Mammalian expression system and the target gene encoding Gln32-Leu360 is expressed with a 6His tag at the C-terminus. CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus; and herpes simplex virus2 (HSV2); involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule; CD112 is found concentrated in adherens junctions; and exists on neurons; endothelial cells;epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226); and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php