Recombinant Human Urokinase Plasminogen Activator Surface Receptor/uPAR (C-6His)
Produktgrößen
10 µg
£514,00
32-7348-10UG
50 µg
£737,00
32-7348-50UG
Über dieses Produkt
- SKU:
- 32-7348
- Weitere Details:
- Source: Human Cells. MW :32.6kD. Recombinant Human PLAUR is produced by our Mammalian expression system and the target gene encoding Leu23-Arg303 is expressed with a 6His tag at the C-terminus. The Urokinase Type Plasminogen Activator (uPA) receptor (uPAR) is a widely expressed receptor for urokinase plasminogen activator (uPA) and pro-uPA. uPAR / CD87 is a highly glycosylated; 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. uPAR is expressed by T-cells; NK cells; monocytes; and neutrophils as well as non-hematopoietic cells that include vascular endothelial cells; fibroblasts; smooth muscle cells; keratinocytes; placental trophoblasts; hepatocytes; and a wide variety of tumor cells (including breast; colon; and prostate carcinoma; melanoma). It plays a critical role in the regulation of cell-surface plasminogen activation in physiological and pathological conditions; and it is also involved in cellular adhesion; the transmission of extracellular signals across the plasma membrane and the subsequent regulation of gene expression. uPAR has been implicated in several biological processes including angiogenesis; monocyte migration; cancer metastasis; trophoblast implantation; and wound healing. Human uPAR is encoded as a 313 amino acid residue polypeptide; excluding a 22 residue signal peptide and shows 60-70% similarity with the murine uPAR amino acid sequence although binding of uPA to uPAR shows strong species specificity.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php