Recombinant Human Matrix Metalloproteinase-1/MMP-1 (C-6His)
Produktgrößen
10 µg
£612,00
32-7342-10UG
50 µg
£919,00
32-7342-50UG
Über dieses Produkt
- SKU:
- 32-7342
- Weitere Details:
- Source: Human Cells. MW :52.88kD. Recombinant Human Matrix Metalloproteinase-1 is produced by our Mammalian expression system and the target gene encoding Phe20-Asn469 is expressed with a 6His tag at the C-terminus. Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts; keratinocytes; endothelial cells; monocytes and macrophages. MMP1 contains several distinct domains: a prodomain that is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region; and a carboxyl terminal (hemopexin like) domain. MMP-1 can degrade a broad range of substrates including types I; II; III; VII; VIII; and X collagens as well as casein; gelatin; a1 antitrypsin; myelin basic protein; L-Selectin; pro-TNF; IL1; IGFBP3; IGFBP5; pro-MMP2; and pro-MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling; characterized by the cleavage of the interstitial collagen triple helix into 3/4; 1/4 fragments. MMP1 may also be involved in enzyme cascades; cytokine regulation and cell surface molecule modulation.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Assay Kits:MMP
- Datenblatt des Herstellers:download_pdf.php