Recombinant Human SLAM Family Member 7/SLAMF7/CD319/CRACC (C-6His)
Produktgrößen
10 µg
£477,00
32-7292-10UG
50 µg
£625,00
32-7292-50UG
Über dieses Produkt
- SKU:
- 32-7292
- Weitere Details:
- Source: Human Cells. MW :23.3kD. Recombinant Human SLAMF7 is produced by our Mammalian expression system and the target gene encoding Ser23-Ser225 is expressed with a 6His tag at the C-terminus. SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells; activated B-cells; NK-cell line but not in promyelocytic; B-cell lines; or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM); which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A); it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However; in the absence of EAT-2; CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells; which are typically devoid of EAT-2. Thus; SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php