Recombinant Human Vascular Cell Adhesion Protein 1/VCAM-1/CD106/L1CAM (C-6His)
Produktgrößen
10 µg
£456,00
32-7285-10UG
50 µg
£562,00
32-7285-50UG
Über dieses Produkt
- SKU:
- 32-7285
- Weitere Details:
- Source: Human Cells. MW :75.26kD. Recombinant Human Vascular Cell Adhesion Protein 1 is produced by our Mammalian expression system and the target gene encoding Phe25-Glu698 is expressed with a 6His tag at the C-terminus. VCAM-1 is a single-pass type I membrane protein; contains 7 Ig-like C2-type domains. It is an endothelial ligand for very late antigen-4 (VLA-4) and a4 beta7 integrin expressed on leukocytes; and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease; atherosclerosis; allograft rejection; infection; and asthmatic responses. During these responses; VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target; the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition; VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules
- Datenblatt des Herstellers:download_pdf.php