Recombinant Human Fibroblast Growth Factor 21/FGF-21 (N-6His)
Produktgrößen
10 µg
£488,00
32-7201-10UG
50 µg
£636,00
32-7201-50UG
Über dieses Produkt
- SKU:
- 32-7201
- Weitere Details:
- Source: E.coli. MW :21.69kD. Recombinant Human Fibroblast Growth Factor 21 is produced by our E.coli expression system and the target gene encoding His29-Ser209 is expressed with a 6His tag at the N-terminus. Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues; by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes; protects animal from diet-induced obesity when overexpression in transgenic mice; and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation; or following the ingestionof a highly-fat/low-carbohydrate diet.Upon FGF21 secretion; white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes; they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies; release; and transported to peripheral tissue for TCA processing and energy generation.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php