Recombinant Human Cyclin-Dependent Kinase 2/CDK2 (N-6His)
Produktgrößen
10 µg
£612,00
32-7189-10UG
50 µg
£919,00
32-7189-50UG
Über dieses Produkt
- SKU:
- 32-7189
- Weitere Details:
- Source: E.coli. MW :36.1kD. Recombinant Human Cyclin-Dependent Kinase 2 is produced by our E.coli expression system and the target gene encoding Met1-Leu298 is expressed with a 6His tag at the N-terminus. Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex; whose activity is restricted to the G1-S phage of the cell cycle; it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit; its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells; such as neurons; thymocytes and endothelial cells.
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php