Recombinant Human Small Ubiquitin-Related Modifier 2/SUMO2 (N-6His)
Produktgrößen
10 µg
£414,00
32-7154-10UG
50 µg
£434,00
32-7154-50UG
Über dieses Produkt
- SKU:
- 32-7154
- Weitere Details:
- Source: E.coli. MW :13kD. Recombinant Human SUMO2 is produced by our E.coli expression system and the target gene encoding Met1-Gly93 is expressed with a 6His tag at the N-terminus. Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small; related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I; and can be promoted by an E3 ligase such as PIAS1-4; RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport; DNA replication and repair; mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Hersteller:
- Abeomics
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Datenblatt des Herstellers:download_pdf.php