FGFR3 Human; His
Produktgrößen
2 µg
£452,00
32-6974-2UG
10 µg
£528,00
32-6974-10UG
Über dieses Produkt
- SKU:
- 32-6974
- Zusätzliche Namen:
- CD333 Antigen; HSFGFR3EX; EC 2.7.10; CD333; CEK2; ACH; Fibroblast Growth Factor Receptor 3; EC 2.7.10.1; FGFR-3; JTK4; Fibroblast Growth Factor Receptor 3 Variant 4; Achondroplasia; Thanatophoric Dwarfism; Hydroxyaryl-Protein Kinase; Tyrosine Kinase JTK4.
- Weitere Details:
- Source: Sf9; Baculovirus cells.Sterile Filtered colorless solution.Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes; including cell growth; differentation; angiogenesis; wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family if type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors; FGFR-1to -4 are known. Multiple forms of FGFR-1 to -3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGFR-1 and -2 results in receptors containing all three Ig domains; referred to as the alpha isoform; or only IgII and IgIII; referred to as the isoform. Only the alpha isoform has been identified for FGFR-3 and FGFR-4. Additional splicing events for FGFR-1 to -3; involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons; generate FGF receptors with alternative IgIII domains (IIIb and IIIc). A IIIa isoform which is a secreted FGF binding protein containing only the N-terminal half of the IgIII domain plus some intron sequences has also been reported for FGFR-1. Mutations in FGFR-1 to -3 have been found in patients with birth defects involving craniosynostosis.FGFR3 Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 592 amino acids (23-375a.a.) and having a molecular mass of 65.1kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). FGFR3 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php