MMP9 Human; HEK
Produktgrößen
2 µg
£452,00
32-6850-2UG
10 µg
£528,00
32-6850-10UG
Über dieses Produkt
- SKU:
- 32-6850
- Zusätzliche Namen:
- Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; Gelatinase B; GELB; MMP9; CLG4B.
- Weitere Details:
- Source: HEK293 Cells.Filtered White lyophilized (freeze-dried) powder.Matrix metalloproteinases are a family of zinc and calcium-dependent endopeptidases that break down extracellular matrix proteins. The MMP9 is secreted as a 92kDa zymogen. Cleavage of ProMMP-9 results in the active enzyme; having a molecular weight of approximately 82kDa. MMP9 is composed of the following domains: a gelatin-binding domain consisting of three fibronectin type II units; a catalytic domain containing the zinc-binding site; a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by the several cell types: monocytes; macrophages; neutrophils; keratinocytes; fibroblasts; osteoclasts and endothelial cells. MMP9 is involved in inflammatory responses; tissue remodeling; wound healing; tumor growth and metastasis. MMP9 may also play an important part in local proteolysis of the extracellular matrix and in leukocyte migration; as well as in bone osteoclastic resorption. MMP9 cleaves type IV and type V collagens into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. MMP9 can also degrade fibronectin but not laminin or Pz-peptide.MMP9 defects may be a cause of susceptibility to intervertebral disc disease (IDD); also known as lumbar disk herniation (LDH).MMP9 Human Recombinant is a single; glycosylated polypeptide chain containing 694 amino acids (20-707a.a) and having a molecular mass of 77.2kDa (calculated). MMP9 is fused to a 6 a.a His tag at C-terminal.
- Aufreinigung:
- Greater than 95.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store lyophilized protein at -20[o]C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4[o]C for a limited period of time; it does not show any change after two weeks at 4[o]C.
- Hersteller:
- Abeomics
- Typ:
- Assay Kits:MMP
- Datenblatt des Herstellers:download_pdf.php