GSTP1 Mouse
Produktgrößen
5 µg
£452,00
32-6788-5UG
20 µg
£528,00
32-6788-20UG
Über dieses Produkt
- SKU:
- 32-6788
- Zusätzliche Namen:
- Glutathione S-transferase P 1; Gst P1; GST YF-YF; GST class-pi; GST-piB; Preadipocyte growth factor.
- Weitere Details:
- Source: Escherichia Coli.Sterile Filtered colorless solution.GSTP1 is a polymorphic gene encoding active; functionally different GSTP1 variant proteins that are believed to function in xenobiotic metabolism and have a part in susceptibility to cancer; and other diseases. GSTP1 is a glutathione S-transferase belonging to the pi class. GST family enzymes play a significant role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based upon the biochemical; immunologic and structural properties of the soluble GSTs they are grouped into 4 main classes: alpha; mu; pi; and theta. The GSTP1 enzyme acts by catalyzing the reaction of glutathione with an acceptor molecule to form a Sulfur-substituted glutathione. The reactions employing glutathione contribute the transformation of a broad range of electrophiles; including reactive products of lipid; protein; carcinogens; therapeutic drugs; environmental toxins; and products of oxidative stress.The GSTP1 inactivation through CpG hypermethylation is frequent in pituitary adenomas and may be a factor in aggressive pituitary tumor behavior. GSTP1 is may be a transcriptional target of the p53 tumor suppressor gene. Single-nucleotide polymorphism in GSTP1 is linked to modified protein binding; which influence GSTP1's contribution to carcinogen and drug metabolism; and possibly disease pathogenesis and/or drug response. GST-pi might have central roles in proliferation of androgen-independent human prostate cancer cells.GSTP1 Mouse Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 233 amino acids (1-210 a.a) and having a molecular mass of 26kDa. GSTP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php