AKR1B1 Mouse
Produktgrößen
5 µg
£452,00
32-6652-5UG
20 µg
£528,00
32-6652-20UG
Über dieses Produkt
- SKU:
- 32-6652
- Zusätzliche Namen:
- Aldose reductase; AKR1B1; AR; Aldehyde reductase; Akr1b3; Aldor1; Aldr1; Akr1b1; Ahr-1; Ahr1; ALR2.
- Weitere Details:
- Source: E.coli.Sterile Filtered colorless solution.AKR1B1 is part of the aldo/keto reductase superfamily; which consists of more than 40 known enzymes and proteins. AKR1B1 catalyzes the reduction several aldehydes; including the aldehyde form of glucose; and thus involved in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. AKR1B1 catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Transgenic mice over expressing human aldose reductase show that AKR1B1 is a key player in ischemic injury and impairment of functional and metabolic recovery after ischemia. Aldose Reductase is an obligatory mediator of TNF-alpha signaling leading to an increase in the expression of adhesion molecules and increased binding of monocytes to the endothelium. AKR1B1 is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.AKR1B1 Mouse Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 339 amino acids (1-316a.a.) and having a molecular mass of 38.1kDa.AKR1B1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 95% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php