IL 29 Human; Sf9
Produktgrößen
2 µg
£452,00
32-6473-2UG
10 µg
£528,00
32-6473-10UG
Über dieses Produkt
- SKU:
- 32-6473
- Zusätzliche Namen:
- Interleukin-29; IL-29; IFN-Lambda 1; Interferon-Lambda 1; Cytokine ZCYTO21; IL29; IFNL1; ZCYTO21.
- Weitere Details:
- Source: Sf9; Baculovirus cells.Sterile filtered colorless solution.IL-29 is distantly related to type I interferons and the IL-10 family. Expression of IL-29 is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor; beta (IL10RB) and interleukin 28 receptor; alpha. IL-29 exhibits common features with type I IFNs such as antiviral activity; antiproliferative activity and in vivo antitumour activity.IL-29 acts similarly to IFNs; but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1; IFN-lambda 2 and IFN-lambda3 are closely positioned genes on human chromosome 19.IL-29 induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells; in an IFN-gamma-independent manner. IL-29 is able to generate tolerogenic DCs; an activity that could thwart IFN-beta functions. IL-29 produced in response to viral infection; activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection. IFN-Lambda 1 antiviral and antiproliferative activity requires Interferon-Lambda 2 receptor tyrosine residues.Interleukin-29 Human Recombinant produced in Sf9 Baculovirus cells is a single; glycosylated polypeptide chain containing 187 amino acids (20-200a.a.) and having a molecular mass of 20.8kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).IL29 is fused with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 90.0% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks. Store; frozen at -20[o]C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php