IL 29 Human; His
Produktgrößen
5 µg
£452,00
32-6472-5UG
20 µg
£528,00
32-6472-20UG
Über dieses Produkt
- SKU:
- 32-6472
- Zusätzliche Namen:
- Interferon lambda-1; IL-29; IL29; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29.
- Weitere Details:
- Source: Escherichia Coli.Sterile filtered colorless solution.IL-29 is distantly related to type I interferons and the IL-10 family. Expression of IL-29 is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor; beta (IL10RB) and interleukin 28 receptor; alpha. IL-29 exhibits common features with type I IFNs such as antiviral activity; antiproliferative activity and in vivo antitumour activity.IL-29 acts similarly to IFNs; but is less effective generally and has activity in a more limited range of cell lines. IFN-ambda 1; IFN-lambda 2 and IFN-lambda3 are closely positioned genes on human chromosome 19.IL-29 induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells; in an IFN-gamma-independent manner.IL-29 is able to generate tolerogenic DCs; an activity that could thwart IFN-beta functions. IL-29 produced in response to viral infection; activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.IFN-Lambda 1 antiviral and antiproliferative activity requires Interferon-Lambda 2 receptor tyrosine residues.IL 29 Human Recombinant produced in E.Coli is a single; non-glycosylated polypeptide chain containing 206 amino acids (20-200 a.a) and having a molecular mass of 22.7kDa.IL 29 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 85% as determined by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4[o]C if entire vial will be used within 2-4 weeks.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php