CTF1 Human
Produktgrößen
2 µg
£452,00
32-6324-2UG
10 µg
£528,00
32-6324-10UG
Über dieses Produkt
- SKU:
- 32-6324
- Zusätzliche Namen:
- CTF1; CT1; CT-1; Cardiophin 1; Cardiotrophin-1.
- Weitere Details:
- Source: Escherichia Coli. Sterile Filtered White lyophilized (freeze-dried) powder. Cardiotrophin 1 (CT-1) is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT 1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT 1 activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes.CT 1 has also a neurotrophic function. CTF1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover; CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. Cardiotrophin 1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. Cardiotrophin 1 can induce expression of the protective heat shock proteins (hsps) in cardiac cells.Cardiotrophin-1 increased ventricular expression of ANP; brain natriuretic peptide (BNP) and angiotensinogen mRNA.Cardiophin 1 levels were significantly elevated in patients with heart failure; patients with dilatative cardiomyopathy; moderate/severe mitral regurgitation; stable and unstable angina and after acute myocardial infarction. Cardiotrophin-1 Human Recombinant produced in E.coli is a single; non-glycosylated; polypeptide chain containing 201 amino acids and having a molecular mass of 21.2kDa.The CTF1 is purified by proprietary chromatographic techniques.
- Aufreinigung:
- Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized CTF1 although stable at room temperature for 3 weeks; should be stored desiccated below -18[o]C. Upon reconstitution CTF-1 should be stored at 4[o]C between 2-7 days and for future use below -18[o]C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
- Hersteller:
- Abeomics
- Typ:
- Antibodies:Monoclonal Antibody
- Datenblatt des Herstellers:download_pdf.php